We observed 911 all-cause deaths among 1649 ovarian cancer cases. We calculated hazard ratios (HRs) using Cox-proportional hazards models. We assessed pre-diagnostic reproductive and hormonal factors during in-person interviews. We followed 1649 invasive epithelial ovarian cancer cases who were enrolled between 19 for overall mortality within the New England Case-Control Study and abstracted chemotherapy data on a subset ( n=449). Therefore, we evaluated pre-diagnostic reproductive and hormonal factors with overall survival and, additionally, platinum-chemotherapy resistance. The previous literature on pre-diagnostic reproductive factors and ovarian cancer survival has been mixed. Ovarian cancer survival is poor, particularly for platinum-resistant cases.
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